Welcome to the TP53 Mutant Loss Of Activity Database

TP53 Mutant Loss Of Activity Database (TP53MutLoad) is a novel database dedicated to the activity of all TP53 mutants.

Thousands of publications have demonstrated that TP53 mutations have multiple heterogeneous consequences on TP53 activities. Each mutant TP53 is a unique protein with highly specific features that combine a mix of various gains and losses of functions.
This novel database compiles the entire TP53 literature on all aspects of mutant TP53 loss or gain of function (see Table below).

You can browse the database using a user-friendly interface and access all data for your favourite TP53 mutant. Data can be easily printed or saved as an Excel sheet or as a pdf file.

Download Here the Documentation

A quick introductory video is available


26 different TP53 activities can be adressed with TP53Mutload

Biological Activity

  • Growth arrest
  • Dominant negative activity for growth arrest
  • Apoptosis
  • Dominant negative activity for apoptosis
  • Autophagy
  • Localisation
  • Activity on mitochondria


  • Binding to hsp70
  • Binding to Pab1620
  • Binding to Pab240
  • Folding
  • Oligomerization
  • Protein binding
  • Modification
  • Thermosensitivity
  • Exonuclease

Biochemical Actvity

  • Transactivation
  • Dominant negative activity for transactivation
  • In vitro DNA binding
  • In vivo DNA binding

Gain of Function

  • Mutant-specific transactivation
  • Interference with p73 and p63
  • Mutant-specific DNA binding
  • Mutant-specific protein binding
  • Mutant-specific activity
  • Mutant p53 KO phenotype

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