The NCI 60 Panel

 

786-0

NCI-60 panel; controversial status between the CCLE and COSMIC databases

2946

2831

3522

3817

3964

c.742C>T

c.[560-2A>G(;)832C>G]

Wild Type

c.[742C>T(;)832C>G]

c.[560-2A>G(;)832C>G]

p.R248W

p.[?(;)P278A]

Wild Type

p.[R248W(;)P278A]

p.[?(;)P278A]

 

BT-549

NCI-60 panel; controversial status between the CCLE and COSMIC databases; included in the Breast Cancer p53 Hotspot Mutation Cell Panel (ATCC® TCP-2010TM) with a mutation in accordance with the COSMIC database

2946

2831

2674

3522

3817

4106

Wild Type

c.747G>C

c.747G>T

c.747G>C

c.747G>C

c.747G>C

Wild Type

p.R249S

p.R249S

p.R249S

p.R249S

p.R249S

 

COLO-205

NCI-60 panel; controversial status between the CCLE and COSMIC databases; controversial status in the literature; the p.G266E mutant described by O'Connor et al. in 1997 is artefactual and has not been included in the database; this cell line was derived from the same patient as COLO-201

2946

2831

782

3522

3817

Wild Type

c.308_333del26Ins2

Wild Type

Wild Type

Wild Type

Wild Type

p.(S103fs)

Wild Type

Wild Type

Wild Type

 

HCC-2998

NCI-60 panel; controversial status

2946

2831

3522

3964

no data

c.637C>T

Wild Type

c.637C>T

no data

p.R213*

Wild Type

p.R213*

 

HCT-15

NCI-60 panel; controversial status between the CCLE and COSMIC databases; controversial status as the splice mutation is often missed; the four cell lines DLD-1 (CCL-221), HCT-15 (CCL-225), HCT-8 (CCL-244) and HRT-18 have been shown to have a common genetic origin

2946

2831

3129

3522

3817

3964

4106

c.722C>T

c.[722C>T(;)1101-2A>C]

c.722C>T

Wild Type

c.722C>T

c.722C>T

c.722C>T

p.S241F

p.[S241F(;)?]

p.S241F

Wild Type

p.S241F

p.S241F

p.S241F

 

HOP-62

NCI-60 panel; controversial status

2946

2831

3522

3817

no data

c.673-2A>G

c.673-2A>G

Wild Type

no data

p.?

p.?

Wild Type

 

IGROV-1

NCI-60 panel; controversial status between the CCLE and COSMIC databases

2946

2831

851

3522

3817

c.377A>G

c.[267_268ins1(;)377A>G]

Wild Type

Wild Type

c.377A>G

p.Y126C

p.[(S90Lfs*59)(;)Y126C]

Wild Type

Wild Type

p.Y126C

 

KM12

NCI-60 panel; controversial status between the CCLE and COSMIC v71 databases; mutation c.210delT is not included in COSMIC v73

2946

2831

3522

3817

3964

4106

c.536A>G

c.[210_210del1(;)216_216del1(;)536A>G]

Wild Type

c.536A>G

c.536A>G

c.216_216del1

p.H179R

p.[(V73Wfs*50)(;)(V73Wfs*50)(;)H179R]

Wild Type

p.H179R

p.H179R

p.(V73Wfs*50)

 

M14

NCI-60 panel; MDA-MB-435 and its derivatives MDA-N and MDA-MD-435S as well as M14 are identical and derived from a melanoma; controversy with other studies

2946

2831

3522

3964

no data

c.797G>A

Wild Type

c.797G>A

no data

p.G266E

Wild Type

p.G266E

 

MOLT-4

NCI-60 panel; controversial status between the CCLE and COSMIC databases; highly controversial status; MOLT-4 was derived from a relapse of the same patient as the MOLT-3 cell line (ATCC CRL-1552)

2946

2831

10

2293

3522

3964

4106

Wild Type

c.916C>T

Wild Type

c.331C>G

Wild Type

c.916C>T

c.916C>T

Wild Type

p.R306*

Wild Type

p.L111V

Wild Type

p.R306*

p.R306*

 

NCI-ADR-RES

NCI-60 panel; originally named MCF-7/AdrR cells, later re-designated NCI/ADR-RES. It was recently found to be identical to OVCAR-8; controversial status

2946

2831

3522

no data

c.376-1G>A

Wild Type

no data

p.?

Wild Type

 

NCI-H226

NCI-60 panel; TP53 status is similar between the COSMIC and the CCLE databases; controversy with other studies

2946

2831

149

3522

3817

Wild Type

Wild Type

c.473G>T

Wild Type

Wild Type

Wild Type

Wild Type

p.R158L

Wild Type

Wild Type

 

NCI-H322

NCI-H322 and NCI-H3255 share high SNP identity

2946

2831

Wild Type

no data

Wild Type

no data

 

OVCAR-3

NCI-60 panel; controversial status between the CCLE and COSMIC databases

2946

2831

197

3522

3817

3964

Wild Type

c.743G>A

c.743G>A

Wild Type

c.743G>A

c.743G>A

Wild Type

p.R248Q

p.R248Q

Wild Type

p.R248Q

p.R248Q

 

OVCAR-5

NCI-60 panel: controversial status; reported mutated or TP53 null in several publications without precise reference or mutational data

2946

2831

2763

3522

3817

no data

Wild Type

Wild Type

Wild Type

Wild Type

no data

Wild Type

Wild Type

Wild Type

Wild Type

 

SF-268

NCI-60 panel

2946

2831

3522

3817

3964

no data

c.818G>A

Wild Type

c.818G>A

c.818G>A

no data

p.R273H

Wild Type

p.R273H

p.R273H

 

 

SF-539

NCI-60 panel; controversial status; wt in one publication

2946

2831

3522

3817

4106

no data

c.1024_1024del1

c.1024_1024del1

Wild Type

c.1024_1024del1

no data

p.(R342Efs*3)

p.(R342Efs*3)

Wild Type

p.(R342Efs*3)

 

SK-OV-3

NCI-60 panel; controversial status between the CCLE and COSMIC databases

2946

2831

2763

3522

3817

4106

Wild Type

c.267_267del1

c.267_267del1

Wild Type

Wild Type

c.267_267del1

Wild Type

p.(S90Pfs*33)

p.(S90Pfs*33)

Wild Type

Wild Type

p.(S90Pfs*33)

 

SN-12C

NCI-60 panel

2946

2831

3522

no data

c.1006G>T

c.1006G>T

no data

p.E336*

p.E336*

 

SNB-19

NCI-60 panel; controversial status between the CCLE and COSMIC databases; SNB19 and U-373-MG are similar; distribution of SNB-19 has been discontinued by ATCC

2946

2831

400

3522

3964

4106

Wild Type

no data

c.818G>A

Wild Type

c.818G>A

c.818G>A

Wild Type

no data

p.R273H

Wild Type

p.R273H

p.R273H

 

SNB-75

NCI-60 panel; controversial status

2946

2831

3522

no data

c.772G>A

c.772G>A

no data

p.E258K

p.E258K

 

SR-786

NCI-60 panel; controversial status

2946

2831

3109

3522

3817

c.455C>T

Wild Type

c.455C>T

Wild Type

Wild Type

p.P152L

Wild Type

p.P152L

Wild Type

Wild Type

 

SW-620

NCI-60 panel; controversial status between the CCLE and COSMIC databases; SW-480 was isolated from the primary tumors and SW-620 from a lymph node upon recurrence; controversial status as the second mutation P309S is often missed

2946

2831

3129

3522

3817

3964

no data

c.[818G>A(;)925C>T]

c.[818G>A]

Wild Type

c.[818G>A(;)925C>T]

c.[818G>A(;)925C>T]

no data

p.[R273H(;)P309S]

p.[R273H]

Wild Type

p.[R273H(;)P309S]

p.[R273H(;)P309S]

 

U-251-MG

NCI-60 panel; controversial status between the CCLE and COSMIC databases; SNB19 and U-373-MG are similar; distribution of SNB-19 has been discontinued by ATCC

2946

2831

561

2379

3522

3964

4010

4106

Wild Type

c.818G>A

c.818G>A

c.818G>A

Wild Type

c.818G>A

c.818G>A

c.818G>A

Wild Type

p.R273H

p.R273H

p.R273H

Wild Type

p.R273H

p.R273H

p.R273H

 

UACC-62

NCI-60 panel

2946

2831

3522

no data

Wild Type

Wild Type

no data

Wild Type

Wild Type

 

UO-31

NCI-60 panel

2946

2831

3522

no data

Wild Type

Wild Type

no data

Wild Type

Wild Type

 

 

 

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