The NCI 60 Panel
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786-0 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases |
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2946 |
2831 |
3522 |
3817 |
3964 |
|
c.742C>T |
c.[560-2A>G(;)832C>G] |
Wild Type |
c.[742C>T(;)832C>G] |
c.[560-2A>G(;)832C>G] |
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p.R248W |
p.[?(;)P278A] |
Wild Type |
p.[R248W(;)P278A] |
p.[?(;)P278A] |
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BT-549 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; included in the Breast Cancer p53 Hotspot Mutation Cell Panel (ATCC® TCP-2010TM) with a mutation in accordance with the COSMIC database |
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2946 |
2831 |
2674 |
3522 |
3817 |
4106 |
|
Wild Type |
c.747G>C |
c.747G>T |
c.747G>C |
c.747G>C |
c.747G>C |
|
Wild Type |
p.R249S |
p.R249S |
p.R249S |
p.R249S |
p.R249S |
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COLO-205 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; controversial status in the literature; the p.G266E mutant described by O'Connor et al. in 1997 is artefactual and has not been included in the database; this cell line was derived from the same patient as COLO-201 |
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2946 |
2831 |
782 |
3522 |
3817 |
|
Wild Type |
c.308_333del26Ins2 |
Wild Type |
Wild Type |
Wild Type |
|
Wild Type |
p.(S103fs) |
Wild Type |
Wild Type |
Wild Type |
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HCC-2998 |
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NCI-60 panel; controversial status |
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2946 |
2831 |
3522 |
3964 |
|
no data |
c.637C>T |
Wild Type |
c.637C>T |
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no data |
p.R213* |
Wild Type |
p.R213* |
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HCT-15 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; controversial status as the splice mutation is often missed; the four cell lines DLD-1 (CCL-221), HCT-15 (CCL-225), HCT-8 (CCL-244) and HRT-18 have been shown to have a common genetic origin |
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2946 |
2831 |
3129 |
3522 |
3817 |
3964 |
4106 |
|
c.722C>T |
c.[722C>T(;)1101-2A>C] |
c.722C>T |
Wild Type |
c.722C>T |
c.722C>T |
c.722C>T |
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p.S241F |
p.[S241F(;)?] |
p.S241F |
Wild Type |
p.S241F |
p.S241F |
p.S241F |
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HOP-62 |
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NCI-60 panel; controversial status |
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2946 |
2831 |
3522 |
3817 |
|
no data |
c.673-2A>G |
c.673-2A>G |
Wild Type |
|
no data |
p.? |
p.? |
Wild Type |
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IGROV-1 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases |
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2946 |
2831 |
851 |
3522 |
3817 |
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c.377A>G |
c.[267_268ins1(;)377A>G] |
Wild Type |
Wild Type |
c.377A>G |
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p.Y126C |
p.[(S90Lfs*59)(;)Y126C] |
Wild Type |
Wild Type |
p.Y126C |
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KM12 |
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NCI-60 panel; controversial status between the CCLE and COSMIC v71 databases; mutation c.210delT is not included in COSMIC v73 |
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|
2946 |
2831 |
3522 |
3817 |
3964 |
4106 |
|
c.536A>G |
c.[210_210del1(;)216_216del1(;)536A>G] |
Wild Type |
c.536A>G |
c.536A>G |
c.216_216del1 |
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p.H179R |
p.[(V73Wfs*50)(;)(V73Wfs*50)(;)H179R] |
Wild Type |
p.H179R |
p.H179R |
p.(V73Wfs*50) |
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M14 |
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NCI-60 panel; MDA-MB-435 and its derivatives MDA-N and MDA-MD-435S as well as M14 are identical and derived from a melanoma; controversy with other studies |
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2946 |
2831 |
3522 |
3964 |
|
no data |
c.797G>A |
Wild Type |
c.797G>A |
|
no data |
p.G266E |
Wild Type |
p.G266E |
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MOLT-4 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; highly controversial status; MOLT-4 was derived from a relapse of the same patient as the MOLT-3 cell line (ATCC CRL-1552) |
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2946 |
2831 |
10 |
2293 |
3522 |
3964 |
4106 |
|
Wild Type |
c.916C>T |
Wild Type |
c.331C>G |
Wild Type |
c.916C>T |
c.916C>T |
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Wild Type |
p.R306* |
Wild Type |
p.L111V |
Wild Type |
p.R306* |
p.R306* |
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NCI-ADR-RES |
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NCI-60 panel; originally named MCF-7/AdrR cells, later re-designated NCI/ADR-RES. It was recently found to be identical to OVCAR-8; controversial status |
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2946 |
2831 |
3522 |
|
no data |
c.376-1G>A |
Wild Type |
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no data |
p.? |
Wild Type |
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NCI-H226 |
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NCI-60 panel; TP53 status is similar between the COSMIC and the CCLE databases; controversy with other studies |
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2946 |
2831 |
149 |
3522 |
3817 |
|
Wild Type |
Wild Type |
c.473G>T |
Wild Type |
Wild Type |
|
Wild Type |
Wild Type |
p.R158L |
Wild Type |
Wild Type |
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NCI-H322 |
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NCI-H322 and NCI-H3255 share high SNP identity |
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|
2946 |
2831 |
|
Wild Type |
no data |
|
Wild Type |
no data |
|
OVCAR-3 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases |
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2946 |
2831 |
197 |
3522 |
3817 |
3964 |
|
Wild Type |
c.743G>A |
c.743G>A |
Wild Type |
c.743G>A |
c.743G>A |
|
Wild Type |
p.R248Q |
p.R248Q |
Wild Type |
p.R248Q |
p.R248Q |
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OVCAR-5 |
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NCI-60 panel: controversial status; reported mutated or TP53 null in several publications without precise reference or mutational data |
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2946 |
2831 |
2763 |
3522 |
3817 |
|
no data |
Wild Type |
Wild Type |
Wild Type |
Wild Type |
|
no data |
Wild Type |
Wild Type |
Wild Type |
Wild Type |
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SF-268 |
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NCI-60 panel |
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2946 |
2831 |
3522 |
3817 |
3964 |
|
no data |
c.818G>A |
Wild Type |
c.818G>A |
c.818G>A |
|
no data |
p.R273H |
Wild Type |
p.R273H |
p.R273H |
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SF-539 |
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NCI-60 panel; controversial status; wt in one publication |
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2946 |
2831 |
3522 |
3817 |
4106 |
|
no data |
c.1024_1024del1 |
c.1024_1024del1 |
Wild Type |
c.1024_1024del1 |
|
no data |
p.(R342Efs*3) |
p.(R342Efs*3) |
Wild Type |
p.(R342Efs*3) |
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SK-OV-3 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases |
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2946 |
2831 |
2763 |
3522 |
3817 |
4106 |
|
Wild Type |
c.267_267del1 |
c.267_267del1 |
Wild Type |
Wild Type |
c.267_267del1 |
|
Wild Type |
p.(S90Pfs*33) |
p.(S90Pfs*33) |
Wild Type |
Wild Type |
p.(S90Pfs*33) |
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SN-12C |
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NCI-60 panel |
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2946 |
2831 |
3522 |
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no data |
c.1006G>T |
c.1006G>T |
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no data |
p.E336* |
p.E336* |
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SNB-19 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; SNB19 and U-373-MG are similar; distribution of SNB-19 has been discontinued by ATCC |
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2946 |
2831 |
400 |
3522 |
3964 |
4106 |
|
Wild Type |
no data |
c.818G>A |
Wild Type |
c.818G>A |
c.818G>A |
|
Wild Type |
no data |
p.R273H |
Wild Type |
p.R273H |
p.R273H |
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SNB-75 |
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NCI-60 panel; controversial status |
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2946 |
2831 |
3522 |
|
no data |
c.772G>A |
c.772G>A |
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no data |
p.E258K |
p.E258K |
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SR-786 |
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NCI-60 panel; controversial status |
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|
2946 |
2831 |
3109 |
3522 |
3817 |
|
c.455C>T |
Wild Type |
c.455C>T |
Wild Type |
Wild Type |
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p.P152L |
Wild Type |
p.P152L |
Wild Type |
Wild Type |
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SW-620 |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; SW-480 was isolated from the primary tumors and SW-620 from a lymph node upon recurrence; controversial status as the second mutation P309S is often missed |
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|
2946 |
2831 |
3129 |
3522 |
3817 |
3964 |
|
no data |
c.[818G>A(;)925C>T] |
c.[818G>A] |
Wild Type |
c.[818G>A(;)925C>T] |
c.[818G>A(;)925C>T] |
|
no data |
p.[R273H(;)P309S] |
p.[R273H] |
Wild Type |
p.[R273H(;)P309S] |
p.[R273H(;)P309S] |
|
U-251-MG |
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NCI-60 panel; controversial status between the CCLE and COSMIC databases; SNB19 and U-373-MG are similar; distribution of SNB-19 has been discontinued by ATCC |
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|
2946 |
2831 |
561 |
2379 |
3522 |
3964 |
4010 |
4106 |
|
Wild Type |
c.818G>A |
c.818G>A |
c.818G>A |
Wild Type |
c.818G>A |
c.818G>A |
c.818G>A |
|
Wild Type |
p.R273H |
p.R273H |
p.R273H |
Wild Type |
p.R273H |
p.R273H |
p.R273H |
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UACC-62 |
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|
NCI-60 panel |
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|
2946 |
2831 |
3522 |
|
no data |
Wild Type |
Wild Type |
|
no data |
Wild Type |
Wild Type |
|
UO-31 |
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|
NCI-60 panel |
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|
2946 |
2831 |
3522 |
|
no data |
Wild Type |
Wild Type |
|
no data |
Wild Type |
Wild Type |