Welcome to the novel TP53 website

After 20 years of existence with more than 4 million pages visited, the old TP53 website (http://p53.free/.fr) has been closed and has been replaced by its successor (p53.fr)

The new TP53 website has been launched with a novel design, updated information and improved readability. This site still includes former features, such as TP53 history, TP53 information or the TP53 mutation database, but these features have been updated to take into account the most recent developments in this exciting field.
Novel features and tools include the TP53 cell line compendium, a revised version of TP53 mutation assessor and the last issue of the UMD TP53 database with more than 80,000 TP53 mutants (2017 Release).

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Soussi, T. (2014) The TP53 Gene network in a Post-Genomic Era

  

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Soussi, T. (2014) Locus-Specific Databases in Cancer: What Future in a Post-Genomic Era?

 The TP53 LSDB Paradigm. 

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Leroy B, Anderson M, Soussi T (2014)

 TP53 Mutations in Human Cancer:

Database Reassessment and Prospects for the Next Decade.

 

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Kamihara, J., Rana, H.Q., and Garber, J.E. (2014)

Germline TP53 Mutations and the Changing Landscape of Li-Fraumeni Syndrome

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Malcikova J, Pavlova S, Kozubik KS, Pospisilova S (2014)

TP53 Mutation Analysis in Clinical Practice:

Lessons From Chronic Lymphocytic Leukemia.

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Eischen CM, Lozano G (2014)

The Mdm Network and its Regulation of p53 Activities:

A Rheostat of Cancer Risk.

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Nguyen, T.A., Menendez, D., Resnick, M.A., and Anderson, C.W. (2014).

Mutant TP53 Posttranslational Modifications : Challenges and Opportunities.

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Candi, E., Agostini, M., Melino, G., and Barnassola, F., (2014).

How the TP53 Family Proteins TP63 and TP73 Contribute to Tumorigenesis : 

Regulators and Effectors.

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Candi E, Agostini M, Melino G, and Barnassola F (2014).

TP53 Mutants in the Tower of Babel of Cancer Progression.

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Donehower LA (2014).

Insights into Wild-Type and Mutant p53 Functions Provided by Genetically Engineered Mice.

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Leroy B, Girard L, Hollestelle A, Minna JD, Gazdar AF, Soussi T (2014).

Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment.

 

    HUMAN MUTATION 2014 TP53 SPECIAL ISSUE   

Soussi T, Leroy B, Taschner PE (2014).

Recommendations for Analyzing and Reporting TP53 Gene Variants in the High Throughput Sequencing Era. 

Please check our new recommendations for the analysis and the validation of TP53 mutation in human cancer:

Leroy, B., Ballinger, M. L., Baran-Marszak, F., Bond, G. L., Braithwaite, A., Concin, N., Donehower, L. A., El-Deiry, W. S., Fenaux, P., Gaidano, G., Langerød, A., Hellstrom-Lindberg, E., Iggo, R., Lehmann-Che, J., Mai, P. L., Malkin, D., Moll, U. M., Myers, J. N., Nichols, K. E., Pospisilova, S., Ashton-Prolla, P., Rossi, D., Savage, S. A., Strong, L. C., Tonin, P. N., Zeillinger, R., Zenz, T., Fraumeni, J. F., Taschner, P. E., Hainaut, P., and Soussi, T. (2017).

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.
Cancer Res 6, 1250-1260. 


 Available as an open access here: 

A special issue of Human Mutation has been released: The TP53 Gene Network in the Post-Genomic Era

This special issue on TP53 propels the TP53 gene into the post-genomic era. Several fundamental features of wild-type and mutant proteins and their modifications are reviewed, as well as animal models and clinical aspects such as recommendations for patient care. The complex structure of this gene warrants innovative strategies to infer a more accurate status of human tumors. Recommendations and guidelines for reporting and annotating TP53 variants are also provided to help researchers generate standardized data that are easy to understand, analyze, and exchange across various cancer variant databases.

A graphical summary of the various articles is presented above. All articles are available on open access and can be downloaded here:

http://onlinelibrary.wiley.com/doi/10.1002/humu.2014.35.issue-6/issuetoc

Site Latest News

The novel TP53 web site
28 October 2017
The 16th p53 International Workshop Image Gallery
08 August 2014
More inSite News  

Literature Highlights

literature

Recent publications on TP53 or cancer genomics: a personal choice

 

Read More ...

Events

events

This section provides key information about a selection of cancer meetings and workshops happening throughout the world. 

 

 Read More ...

Go to top