Welcome to Mut_Mat_II

MUT-TP53 2.0, an accurate and powerful tool that will automatically handle p53 mutations and generate tables ready for publication that will lower the risk of typographical errors. MUT-TP53 2.0 has been developed with Excel and will work for both Mac and PC user.

A second version (July 2010) of MUT_MAT is now available:
Soussi T
, Hamroun D, Hjortsberg L, Rubio-Nevado JM, Fournier JL, Beroud C (2010) MUT-TP53 2.0: a novel versatile matrix for statistical analysis of TP53 mutations in human cancer. Hum Mutat 31: 1020-1025.

MUT_MAT 1.0
(2006)
MUT_MAT 2.0
(2010)
Handle p53 sequence to prevent codon miss identification
Yes
Yes
Use genetic code to handle mutations
Yes
Yes
Display functional data for each mutant p53
Yes
Yes
Generate a p53 mutation tables ready for publication
Yes
Yes
Identify every TP53 natural polymorphisms
No
Yes
Cover every single, double or triple nucleotide substitution at each codon of the p53 gene
No
Yes
Include information for TP53 mutant with unusual behavior (T125T, R337H, etc)
No
Yes
Include information for splicing mutation
No
Yes
Compare the profile of p53 inactivation with other publications
No
Yes
Statistical analysis of p53 loss of function
No
Yes

Download
MUT-TP53 2.0
The documentation
MUT-TP53 2.0 with data
The manuscript

Output example: Ten mutant p53 showing the various features of MUT-MAT V2.0 were analyzed. Mutants in sample 1 (p.R175H), sample 2 (p.K132E), sample 5 (p.T125T), sample 6 (p.S260S), sample 7 (p.R337H) and sample 8 (p.N200P) have been described in the tumor database. In sample 3, the spreadsheet identifies the exonic SNP in exon 4 at codon 72. In sample 4, the matrix identifies a typographical error, as wt and mutant codon are identical. Mutants in sample 9 and 10 correspond to the substitution of two non-contiguous residues or 3 residues. These mutational events are very unusual in the p53 gene and are flagged accordingly. See text for more information. Nucleotide numbering reflects cDNA numbering with +1 corresponding to the A of the ATG translation initiation codon in the reference sequence (GDB: 120445).