Welcome to the TP53Mutload Database

TP53Mutant Loss Of Activity Database (TP53MutLoad) is a novel database dedicated to the activity of all TP53 mutants. Thousands of publications have demonstrated that TP53 mutations have multiple heterogeneous consequences on TP53 activities. Each mutant TP53 is a unique protein with highly specific features that combine a mix of various gains and losses of functions.
This novel database compiles the entire TP53 literature on all aspects of mutant TP53 loss or gain of function (see Table below).

You can browse the database using a user-friendly interface and access all data for your favourite TP53 mutant. Data can be easily printed or saved as an Excel sheet or as a pdf file.

Download the TP53MUTLOAD manual:
Browse screenshots of the various features of TP53MUTLOAD
A quick introductory video is available

Table: 26 different TP53 activities can be adressed with TP53Mutload

BIOCHEMICAL ACTIVITY

STRUCTURE

Transactivation

Binding to hsp70

Dominant negative activity for transactivation

Binding to Pab1620

In vitro DNA binding

Binding to Pab240

In vivo DNA binding

Folding

 

Oligomerization

 

Protein binding

 

Modification

 

Thermosensitivity

 

Exonuclease

 

 

BIOLOGICAL ACTIVITY

GAIN OF FUNCTION

Growth arrest

Mutant-specific transactivation

Dominant negative activity for growth arrest

Interference with p73 and p63

Apoptosis

Mutant-specific DNA binding

Dominant negative activity for apoptosis

Mutant-specific protein binding

Autophagy

Mutant-specific activity

Localisation

Mutant p53 KO phenotype

Activity on mitochondria